Do you mean a corporate instance of Exchange your company is hosting? If so have the Exchange admins enable IMAPS [1]. I've used Thunderbird with Exchange in the past. The admins can also publish SRV records in AD or DNS to give Thunderbird some hints depending on your corporate configuration vpn vs lan vs public. The use of a VPN should be encouraged to avoid exposing a public endpoint and bots brute-forcing AD accounts leading to lockouts.

For their Microsoft 365 / O365 use [2]

[1] - https://learn.microsoft.com/en-us/exchange/clients/pop3-and-...

[2] - https://support.microsoft.com/en-gb/office/pop-imap-and-smtp...