Androgen insensitivity syndrome means that her cells do not react to testosterone. What male advantage is there if her cells don't react to testosterone?
Soundarajan's androgen insensitivity was reported as being partial (i.e. PAIS, and not CAIS), which implies some degree of testosterone-driven masculinization.
Doesn’t really work though - and given athletes are on the edge of performance there’s probably more people that fall in between than you might expect
From the Wikipedia article:
While the presence or absence of SRY has generally determined whether or not testis development occurs, it has been suggested that there are other factors that affect the functionality of SRY.[25] Therefore, there are individuals who have the SRY gene, but still develop as females, either because the gene itself is defective or mutated, or because one of the contributing factors is defective.[26] This can happen in individuals exhibiting a XY, XXY, or XX SRY-positive[27] karyotype[better source needed]
Additionally, other sex determining systems that rely on SRY beyond XY are the processes that come after SRY is present or absent in the development of an embryo. In a normal system, if SRY is present for XY, SRY will activate the medulla to develop gonads into testes. Testosterone will then be produced and initiate the development of other male sexual characteristics. Comparably, if SRY is not present for XX, there will be a lack of the SRY based on no Y chromosome. The lack of SRY will allow the cortex of embryonic gonads to develop into ovaries, which will then produce estrogen, and lead to the development of other female sexual characteristics.[28]
The Yahoo article linked says that exceptions will be made for people with conditions like that:
“Athletes diagnosed with Complete Androgen Insensitivity Syndrome (CAIS) ‘or other rare differences/disorders in sex development (DSDs), who do not benefit from the anabolic and/or performance-enhancing effects of testosterone’ may still be allowed to participate in the women’s category.”
It can’t be fully secure but you can use a domain or path with a uuid or similar such that no one could guess your dns endpoint, over dot or doh. In theory someone might log your dns query then replay it against your dns server though.
You could also add whitelisting on your dns server to known IPs, or at least ranges to limit exposure, add rate limiting / detection of patterns you wouldn’t exhibit etc.
You could rotate your dns endpoint address every x minutes on some known algorithm implemented client and server side.
But in the end it’s mostly security through obscurity, unless you go via your own tailnet or similar
Why are SaaS margins apparently dropping? The cost of producing saas is going down, no one is investing in new saas companies, the build your own saas will crumble as described in this article, meanwhile corporate IT departments will be decimated to pay for ballooning AI costs leaving saas as the only option to run companies.
Are any saas companies actually reducing their prices?
Great video! This references the fantastic book Flatland, which helps explain dimensionality in really easy to understand way, and helped me get my head around what a 4th or n level dimension is (and why we it’s so unintuitive for us 3-dimensional beings)
yes? it's got sexist and classist elements and satirizes victorian culture.
i'd encourage reading it ahead of gifting (and i'd encourage grabbing it from archive.org or something, since it's 141 years old) because not all 10 yearolds are going to receive it the same way
I'm downloading DeepSeek-V3.2-Speciale now at FP8 (reportedly Gold-medal performance in the 2025 International Mathematical Olympiad and International Olympiad in Informatics).
It will fit in system RAM, and as its mixture of experts and the experts are not too large, I can at least run it. Token/second speed will be slower, but as system memory bandwidth is somewhere around 5-600Gb/s, so it should feel OK.
Check out "--n-cpu-moe" in llama.cpp if you're not familiar. That allows you to force a certain number of experts to be kept in system memory while everything else (including context cache and the parts of the model that every token touches) is kept in VRAM. You can do something like "-c128k -ngl 99 --n-cpu-moe <tuned_amt>" where you find a number that allows you to maximize VRAM usage without OOMing.
This is about more. I can run 600B+ models at home. Today I was having a discussion with my wife and we asked ChatGPT a quick question, it refused because it can't generate the result based on race. I tried to prompt it to and it absolutely refused. I used my local model and got the answer I was looking for from the latest Mistral-Large3-675B. What's the cost of that?
The author was running a quantised version of GLM 4.5 _Air_, not the full fat version. API pricing for that is closer to $0.2/$1.1 at the top end from z.ai themselves, half the price from Novita/SiliconFlow.
I think there are probably Law Firms/doctors offices that would gladly pay ~3-4K euro a month to have this thing delivered and run truely "on-prem" to work with documents they can't risk leaking (patent filings, patient records etc).
For a company with 20-30 people, the legal and privacy protection is worth the small premium over using cloud providers.
Just a hunch though! This would have it paid-off in 3-4 months?
They are based in the UK. That is technically Europe, but I believe for privacy regulations it isn't the same as a EU-country, but I could be very wrong. Would love to be educated on this by someone.
Currently at the millions stage with https://mailpace.com relying mostly on Postgres
Tbh this terrifies me! We don’t just have to log the requests but also store the full emails for a few days, and they can be up to 50 mib in total size.
