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Screening ‘test’ vs diagnostic ‘test’ is an important concept.

Screening tests are designed for sensitivity — false positives are expected and identify who would benefit from additional diagnostic tool and procedures.



Sigh.

s/Delta/United/ or s/Delta/Southwest/ or s/Delta/Lufthansa/. Or if you prefer, s/refinery/oilfield, or s/refinery/pipeline. Or even s/refinery/farm/ because Delta also buys food in vast quantities (I would not be surprised to find they have interests in ag producers that offset a small % of their food purchases, which does not diminish the argument).

Delta also does not make airplanes, jet engines, seats, radios, GPS, glass, or even wires. They don't distill the spirits they serve on their flights. They don't own and operate a satellite Internet capability. They don't even make movies for in-flight entertainment.

The point is that Delta, like most successful firms, outsources key aspects of core service delivery.

The second article you linked says plainly that the refinery is an offset/hedge. QED Delta still outsources the vast majority of its fuel costs. (They could, for example, own large swathes of the Permian and do E&P as well. They choose to leave that to others.)


Vertical integration has been a common practice in industry for 150 years. Yes, very few firms fully control their upstream supply chains, but very few conversely produce nothing but their core market offering in-house. Most companies are somewhere in between, doing some things in-house, and obtaining other things from vendors.

Most large firms have in-house software dev teams responsible for at least some portion of their development work. I know software engineers locally working, variously, at banks, pet supply distributors, power companies, soft drink bottlers, and many other non-tech industries. And AI can and will extend these teams' capacity to internally manager larger segments of their companies' tech stacks.


Lmao I love this flavor of the ‘tism that always surfaces in hn comment threads exactly like this. Like moths to a flame

Whole Genome Sequencing is affordable now. I’d suggest a 20x hifi long read from broad clinical labs for $1200 or so. Use opencravet to dig into the results. They just posted a webinar for personal analysis https://wse.zoom.us/webinar/register/WN_-VvYJ8FKRcGaKCQtLFrU...

Franklin by genoox is a slicker and possibly more approachable product depending on your interface preferences.

Genetic research — due to the number and subtly of variants — is ripe for citizen science in my opinion.


As a follow-on to this:

If you have partial genome data from 23andMe, Ancestry, etc, you can use what's called "genomic imputation" to do a sort of probabilistic gap-filling in your genome.

It's a bit tricky to do yourself, but there are paid services that will run the imputation for you and share the results.

I paid $15 for mine at https://dnagenics.com

---

@codytruscott I signed up for that webinar, I hadn't heard of this tool before, thanks!

Got any other useful links/tools to share by chance?


Rather than 23andMe, Ancestry ($50-$100) etc => imputation, broad clinical labs offers exome + genome blended for $120.

https://usegalaxy.org is pretty remarkable and provides access to a ton of open source bioinformatics tools + compute to process the files.

I really think the $1200 20x pacbio from broad is worth it if you are going to make it serious hobby.


the site i maintain is a bit out of date, but i accept PRs if you have time to add the broad clinical labs data!

https://whichgenome.com/


Thank you for this! My wife recently got a pathology report back reporting a rare variant of a rare cancer and I’m trying to get back into genomics (an almost masters degree) now to see if there’s anything my computering can do to aid. I’ve contacted Broad Clinical Labs.


Reasonably significant transition to PEX piping for domestic water supply starting in 2004 following a surge in copper pipe pricing.


Just guessing here, but I doubt PEX piping is a major contributor, seeing as it's solid plastic that doesn't shed and is rarely exposed to the elements. The most common sources of micro plastics appear to be things like synthetic fibers in clothing, particles coming off of car tires as they wear down, manufactured plastic particulate like micro-beads/glitter, and plastic objects in the ocean that break down into smaller and smaller pieces due to physical abrasion, sun, damage, etc.


This makes me happy I have copper plumbing with nice, healthy 1970s lead solder.


Make sure it's organic, grass fed, lead solder


Seems like a reasonable possibility considering the notable jump in PE in the kidneys.


Phew, glad I only drink water ampoules.


Let this be a lesson to folks. Sales matters. The clear disdain, lack of respect, or perhaps just disinterest for building a solid sales process/pipeline at makerhaus led to it's demise.


This is bogus & unsourced. The minimum wage in Seatac was $9.19/hr in 2013, not $7.


Goto the best school in your country.


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