I like Rails on the back-end (or simpler Ruby-based frameworks like Sinatra) and Vue or Nuxt on the front-end. I have stuff in production with these and they progressed very well from prototype to production.

Right, I forgot to mention Rails. I've always been a bit turned off by Ruby's syntax, but always heard it's awesome in many ways. Thanks!

I love Rails, but if you like and already know Python, then Django is a better choice for you :)

So much of this!