Protillion Biosciences | full-time | San Diego (Carlsbad) | On Site | $150-200k
We're a small, late Series A team generating massive datasets of antibody-protein interactions to engineer next-generation therapeutics. Looking for talented software engineers to lead efforts in drug design and build iterative end-to-end automated discovery workflows. Background in AI/ML required and bioinformatics and protein engineering/design a plus.
What makes our platform unique:
- We're generating massive quantitative datasets on 10^5-10^6 antibody-protein interactions at once. This is about 3 OOM higher than competing platforms.
- We've closed the loop between protein design and data collection with our own custom hardware. We use this to test in-house designed massive antibody libraries with every cycle taking as little as two weeks
- We're a drug discovery company - using our technology to create therapeutics with properties exquisitely tuned to the biological context and needs of patients.
Interested in practical applications of ML to address unmet patient needs in the fastest-growing field of new therapeutics?
I introduced this to so many people as the only one who knew how to play. Key is start the game with 3 cards and win the round quickly + be super diligent about the rules so no conflicting information. Win the round quickly, add an obvious rule and by the third round it's fair play.
I used to play this a ton (often as a drinking game). The wiki does a good job of explaining the basics and I'd always do the no talking + point of order variants (+ a few others). My favorite type are:
1) rules requiring awareness of card order. "Have a nice day" is standard on 7, double 7's is "very nice" etc. Stack rules like that when combinations and/or cards of a suit are played and people have to remember 5 things they have to say or do after a card. Get's difficult over many rounds.
2) ice-breaking rules (if you're playing with new people). Friendly ones like "you must compliment _ when a _ is played." Great way to build/open someone up
3) rules changing play order. Aces reverse, add rules that e.g. skip a player and you'll have everyone waiting in suspense to see if the person who's turn it is actually knows its their turn. If not, "delay of game".
Play it with friends you'll be surprised with what people come up with!
i just picked up an ultimaker s5 for $400 on ebay with tons of extra filament and it worked off the bat. Been printing for almost 2 weeks straight and my daughter loves it :D
Christmas 1999 my father's business had just gone under when the banks stopped lending after the dot com bubble. We didn't have any presents until Christmas morning when our church dropped off a bunch of presents for us. We got a Razor scooter and I spent all day riding it downstairs.
I just got my daughter a scooter and she's doing the same this year :)
Was going to say about the same - this is ~2500 years after construction of the pyramids. How do you coordinate something that massive without any form of writing?
> Was going to say about the same - this is ~2500 years after construction of the pyramids.
The first Egyptian pyramid known was built ~2780 BCE, the alphabetic writing in this article was from ~2500 BCE. That’s a gap of ~250 years, not ~2,500.
> How do you coordinate something that massive without any form of writing?
The Egyptians at the time of the Pyramids had writing, but it was logographic (symbols directly represent a word/concept), not alphabetic (a small inventory of symbols are combined in different ways to represent words/concepts.)
An alphabetic – and also phonetic – script is a big advance not because of what you communicate with it, but because if you know a fairly small set of symbols and their phonetic interpretation, you can encode a spoken language in it in a reasonably intelligible way to anyone who knows the same script (and you can even encode different spoken languages in the same script intelligibly, if they have a similar-enough phonetic inventory.)
I'm no expert, but my understanding is that Coptic made use of hieroglyphs as an alphabet, and co-existed with their use for Egyptian: https://en.wikipedia.org/wiki/Coptic_language
The article is about alphabets. There was writing prior to alphabets, but it was done in hieroglyphics, cuneiform, and characters. Alphabets are easier to learn and therefore more widely used.
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